My laser diode is a blue 445 nm which makes it color dependent as in power absorption. If the acrylic were red and/or possibly opaque it might. I think you would have to try down towards 10640 nm range to work with clear acrylic. The power may be enough, I am not sure. I have run mine around 1/2 to 1 watt but I haven't done much experimenting yet. Drought=golf!
Serial #0054, 2 Watt laser, dual X motors, double Y, ACME Z Axis, G540, Mach 3, rotating axis, Proxxon, 750mm x 375mm, laser cross hairs, auto zero
Ordbot #201, MK7 extruder gone minimalist with MK8 nozzle